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1

Chronopharmacology

Vincent Marks, Judie English, Wynne Aherne, Josephine Arendt

Journal:

Clinical Biochemistry

Year:

1985

Language:

english

File:

PDF, 483 KB

english, 1985

2

High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity

Martin G Rowlands, Yvette M Newbatt, Chrisostomos Prodromou, Laurence H Pearl, Paul Workman, Wynne Aherne

Journal:

Analytical Biochemistry

Year:

2004

Language:

english

File:

PDF, 417 KB

english, 2004

3

Targeting the Hsp90 Chaperone: Synthesis of Novel Resorcylic Acid Macrolactone Inhibitors of Hsp90

James E. H. Day, Swee Y. Sharp, Martin G. Rowlands, Wynne Aherne, Paul Workman, Christopher J. Moody

Journal:

Chemistry - A European Journal

Year:

2010

Language:

english

File:

PDF, 389 KB

english, 2010

4

Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies

Dr. James E. H. Day, Dr. Swee Y. Sharp, Dr. Martin G. Rowlands, Dr. Wynne Aherne, Dr. William Lewis, Dr. S. Mark Roe, Dr. Chrisostomos Prodromou, Prof. Dr. Laurence H. Pearl, Prof. Dr. Paul Workman, P

Journal:

Chemistry - A European Journal

Year:

2010

Language:

english

File:

PDF, 545 KB

english, 2010

5

ChemInform Abstract: Synthesis of Certain 2′-Deoxyuridine Derivatives Containing Substituted Phenoxy Groups Attached to C-5′; Evaluation as Potential dUTP Analogues.

Jonathan H. Marriott, G. Wynne Aherne, Anthea Hardcastle, Michael Jarman

Journal:

Year:

2002

File:

PDF, 33 KB

2002

6

High-Throughput Screening for Identification of Small Molecule Inhibitors of Histone Acetyltransferases Using Scintillating Microplates (FlashPlate)

F. Turlais, Anthea Hardcastle, M. Rowlands, Yvette Newbatt, A. Bannister, T. Kouzarides, P. Workman, G.Wynne Aherne

Journal:

Analytical Biochemistry

Year:

2001

Language:

english

File:

PDF, 98 KB

english, 2001

7

The quantitative determination of 2′-deoxycytidine-5′-triphosphate in cell extracts by radioimmunoassay

Evelyn M. Piall, G.Wynne Aherne, Vincent Marks

Journal:

Analytical Biochemistry

Year:

1986

Language:

english

File:

PDF, 459 KB

english, 1986

8

Immunoassay and its applications to water analysis

Journal:

TrAC Trends in Analytical Chemistry

Year:

1984

Language:

english

File:

PDF, 376 KB

english, 1984

9

Practical immunoassay—the state of the art : (Clinical and Biochemical Analysis Series, Vol. 14), edited by Wilfred R. Butt, Marcel Dekker, 1984. SFR 156.00 (328 pages) ISBN 0-8247-7094-3

Journal:

TrAC Trends in Analytical Chemistry

Year:

1985

Language:

english

File:

PDF, 140 KB

english, 1985

10

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B

Ian Collins, John Caldwell, Tatiana Fonseca, Alastair Donald, Vassilios Bavetsias, Lisa-Jane K. Hunter, Michelle D. Garrett, Martin G. Rowlands, G. Wynne Aherne, Thomas G. Davies, Valerio Berdini, Ste

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 570 KB

english, 2006

11

Structure-Activity Relationships in Purine-Based Inhibitor Binding to HSP90 Isoforms

Lisa Wright, Xavier Barril, Brian Dymock, Louisa Sheridan, Allan Surgenor, Mandy Beswick, Martin Drysdale, Adam Collier, Andy Massey, Nick Davies, Alex Fink, Christophe Fromont, Wynne Aherne, Kathy Bo

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 484 KB

english, 2004

12

Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs)

Stephen Gorsuch, Vassilios Bavetsias, Martin G. Rowlands, G. Wynne Aherne, Paul Workman, Michael Jarman, Edward McDonald

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 237 KB

english, 2009

13

Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2

Stephen Hilton, Sebastien Naud, John J. Caldwell, Kathy Boxall, Samantha Burns, Victoria E. Anderson, Laurent Antoni, Charlotte E. Allen, Laurence H. Pearl, Antony W. Oliver, G. Wynne Aherne, Michelle

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.05 MB

english, 2010

14

Corrigendum to “Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2” [Bioorg. Med. Chem. 18 (2010) 707]

Stephen Hilton, Sebastien Naud, John J. Caldwell, Kathy Boxall, Samantha Burns, Victoria E. Anderson, Laurent Antoni, Charlotte E. Allen, Laurence H. Pearl, Antony W. Oliver, G. Wynne Aherne, Michelle

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 93 KB

english, 2010

15

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

Kwai-Ming J. Cheung, Thomas P. Matthews, Karen James, Martin G. Rowlands, Katherine J. Boxall, Swee Y. Sharp, Alison Maloney, S. Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl, G. Wynne Aherne, E

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 590 KB

english, 2005

16

Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases

Thomas P. Matthews, Tatiana McHardy, Suki Klair, Kathy Boxall, Martin Fisher, Michael Cherry, Charlotte E. Allen, Glynn J. Addison, John Ellard, G. Wynne Aherne, Isaac M. Westwood, Rob van Montfort, M

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 585 KB

english, 2010

17

High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells

S Elaine Barrie, Ebun Eno-Amooquaye, Anthea Hardcastle, Georgina Platt, Juliet Richards, David Bedford, Paul Workman, Wynne Aherne, Sibylle Mittnacht, Michelle D Garrett

Journal:

Analytical Biochemistry

Year:

2003

Language:

english

File:

PDF, 248 KB

english, 2003

18

The effect of food on the oral administration of 6-mercaptopurine

Neil K. Burton, Michael J. Barnett, G. Wynne Aherne, Julienne Evans, Ian Douglas, T. Andrew Lister

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1986

Language:

english

File:

PDF, 200 KB

english, 1986

19

A radioimmunoassay for VP16-213 in plasma

G. Wynne Aherne, Vincent Marks

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1982

Language:

english

File:

PDF, 389 KB

english, 1982

20

The effect of cotrimoxazole on the absorption of orally administered 6-mercaptopurine in the rat

Neil K. Burton, G. Wynne Aherne

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1986

Language:

english

File:

PDF, 169 KB

english, 1986

21

The effect of abolition of the endogenous corticosteroid rhythm on the circadian variation in methotrexate toxicity in the rat

Judie English, G. Wynne Aherne, Jo Arendt, Vincent Marks

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1987

Language:

english

File:

PDF, 313 KB

english, 1987

22

The effect of timing of a single injection on the toxicity of methotrexate in the rat

Judie English, G. Wynne Aherne, Vincent Marks

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1982

Language:

english

File:

PDF, 358 KB

english, 1982

23

Serum kinetics of the anti-cancer agent 4-hydroxyandrostenedione in the rat

Jamal Khubieh, G. Wynne Aherne, Jagadish Chakraborty

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1990

Language:

english

File:

PDF, 278 KB

english, 1990

24

The quantitation by radioimmunoassay of 2′-deoxyuridine 5′-triphosphate in extracts of thymidylate synthase-inhibited cells

Evelyn M. Piall, Nicola J. Curtin, G.Wynne Aherne, Adrian L. Harris, Vincent Marks

Journal:

Analytical Biochemistry

Year:

1989

Language:

english

File:

PDF, 643 KB

english, 1989

25

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

Ali, Maruf M U, Bagratuni, Tina, Davenport, Emma L, Nowak, Piotr R, Silva-Santisteban, M Cris, Hardcastle, Anthea, McAndrews, Craig, Rowlands, Martin G, Morgan, Gareth J, Aherne, Wynne

Journal:

The EMBO Journal

Year:

2011

Language:

english

File:

PDF, 1.53 MB

english, 2011

26

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange

Oliver, Antony W, Paul, Angela, Boxall, Katherine J, Barrie, S Elaine, Aherne, G Wynne, Garrett, Michelle D, Mittnacht, Sibylle, Pearl, Laurence H

Journal:

The EMBO Journal

Year:

2006

Language:

english

File:

PDF, 622 KB

english, 2006

27

A human capecitabine excretion balance and pharmacokinetic study after administration of a single oral dose of 14C-labelled drug

Ian R. Judson, Philip J. Beale, José M. Trigo, Wynne Aherne, Thomas Crompton, David Jones, Ernie Bush, Bruno Reigner

Journal:

Investigational New Drugs

Year:

1999

Language:

english

File:

PDF, 107 KB

english, 1999

28

Structural and mechanistic aspects of phospholipase Cγ regulation

Matilda Katan, Rosie Rodriguez, Miho Matsuda, Yvette M Newbatt, G.Wynne Aherne

Journal:

Advances in Enzyme Regulation

Year:

2003

Language:

english

File:

PDF, 131 KB

english, 2003

29

Histone Deacetylase Inhibitors: Emerging Anticancer Therapeutic Agents?

Rebecca Kristeleit, Peter Fong, G. Wynne Aherne, Johann de Bono

Journal:

Clinical Lung Cancer

Year:

2005

Language:

english

File:

PDF, 1.08 MB

english, 2005

30

Identification of 4-(4-Aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as Selective Inhibitors of Protein Kinase B through Fragment Elaboration

Caldwell, John J., Davies, Thomas G., Donald, Alastair, McHardy, Tatiana, Rowlands, Martin G., Aherne, G. Wynne, Hunter, Lisa K., Taylor, Kevin, Ruddle, Ruth, Raynaud, Florence I.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 862 KB

english, 2008

31

Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B through Structure-Based Design

McHardy, Tatiana, Rowlands, Martin G., Hunter, Lisa-Jane K., Davies, Thomas G., Berdini, Valerio, Boyle, Robert G., Aherne, G. Wynne, Garrett, Michelle D., Collins, Ian, Donald, Alastair

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 253 KB

english, 2007

32

Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells

G.Wynne Aherne, Anthea Hardcastle, Florence Raynaud, Ann L. Jackman

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.29 MB

english, 1996

33

The radioiodination of bleomycin using iodogen

G.Wynne Aherne, Stuart L. James, Vincent Marks

Journal:

Clinica Chimica Acta

Year:

1982

Language:

english

File:

PDF, 189 KB

english, 1982

34

HTS – all you need to know?

Journal:

Trends in Pharmacological Sciences

Year:

2002

Language:

english

File:

PDF, 64 KB

english, 2002

35

A rationale for the clinical development of the thymidylate synthase inhibitor ZD9331 in ovarian and other solid tumours

Ann L Jackman, Camille J Melin, Rosemary Kimbell, Lisa Brunton, G.Wynne Aherne, Davinder S Theti, Mike Walton

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2002

Language:

english

File:

PDF, 284 KB

english, 2002

36

Assays for the identification and evaluation of histone acetyltransferase inhibitors

G Wynne Aherne, Martin G Rowlands, Lindsay Stimson, Paul Workman

Journal:

Year:

2002

Language:

english

File:

PDF, 178 KB

english, 2002

37

DEGREE OF TOLERANCE AND THE RELATIONSHIP BETWEEN PLASMA MORPHINE CONCENTRATION AND PUPIL DIAMETER FOLLOWING INTRAVENOUS HEROIN IN MAN

KATHLEEN H. TRESS, A.A. EL-SOBKY, WYNNE AHERNE, EVELYN PIALL

Journal:

British Journal of Clinical Pharmacology

Year:

1978

Language:

english

File:

PDF, 659 KB

english, 1978

38

Benzimidazole Inhibitors Induce a DFG-Out Conformation of Never in Mitosis Gene A-Related Kinase 2 (Nek2) without Binding to the Back Pocket and Reveal a Nonlinear Structure−Activity Relationship

Solanki, Savade, Innocenti, Paolo, Mas-Droux, Corine, Boxall, Kathy, Barillari, Caterina, van Montfort, Rob L. M., Aherne, G. Wynne, Bayliss, Richard, Hoelder, Swen

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.21 MB

english, 2011

39

Immunochemical analysis of water micropollution

Journal:

Science of The Total Environment

Year:

1993

Language:

english

File:

PDF, 612 KB

english, 1993

40

Finding the needle in the haystack: why high-throughput screening is good for your health

G Wynne Aherne, Edward McDonald, Paul Workman

Journal:

Breast Cancer Research

Year:

2002

Language:

english

File:

PDF, 210 KB

english, 2002

41

4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

Brough, Paul A., Aherne, Wynne, Barril, Xavier, Borgognoni, Jenifer, Boxall, Kathy, Cansfield, Julie E., Cheung, Kwai-Ming J., Collins, Ian, Davies, Nicholas G. M., Drysdale, Martin J., Dymock, Brian,

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.08 MB

english, 2008

42

Histone modification enzymes: novel targets for cancer drugs

Kristeleit, Rebecca, Stimson, Lindsay, Workman, Paul, Aherne, Wynne

Journal:

Expert Opinion on Emerging Drugs

Year:

2004

Language:

english

File:

PDF, 544 KB

english, 2004

43

Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies

Day, James E. H., Sharp, Swee Y., Rowlands, Martin G., Aherne, Wynne, Hayes, Angela, Raynaud, Florence I., Lewis, William, Roe, S. Mark, Prodromou, Chrisostomos, Pearl, Laurence H., Workman, Paul, Moo

Journal:

ACS Chemical Biology

Year:

2011

Language:

english

File:

PDF, 4.69 MB

english, 2011

44

Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of a Novel Histone Deacetylase Inhibitor, LAQ824, in Human Colon Carcinoma Cells and Xenografts

Chung, Yuen-Li, Troy, Helen, Kristeleit, Rebecca, Aherne, Wynne, Jackson, L. Elizabeth, Atadja, Peter, Griffiths, John R., Judson, Ian R., Workman, Paul, Leach, Martin O., Beloueche-Babari, Mounia

Journal:

Year:

2008

Language:

english

File:

PDF, 624 KB

english, 2008

45

MORPHINE-6-GLUCURONIDE, AN IMPORTANT FACTOR IN INTERPRETING MORPHINE RADIOIMMUNOASSAYS

Aherne, G.Wynne, Littleton, P.

Journal:

Year:

1985

Language:

english

File:

PDF, 349 KB

english, 1985

46

OPIOID METABOLISM AND THE KIDNEY

Barnes, J.N., Williams, A.J., Wynne Aherne, G., Hanks, G.W., Michie, C., Chapman, J.R., Sear, J., Moore, R.A.

Journal:

Year:

1985

Language:

english

File:

PDF, 132 KB

english, 1985

47

Book reviews

Aherne, G. Wynne, Uden, Peter C., Simpson, D., Sadler, Peter J., Simpson, D., Lloyd, G. O., Ackland, G. J., Christopher, N. S. J., Smith, Roger M., Smyth, Malcolm R., Preston, Martin R., van den Berg,

Journal:

The Analyst (Royal Society of Chemistry)

Year:

1993

Language:

english

File:

PDF, 903 KB

english, 1993

48

Enhanced chemiluminescent enzyme immunoassay for cannabinoids in urine

Sharma, Jai D., Aherne, G. Wynne, Marks, Vincent

Journal:

The Analyst (Royal Society of Chemistry)

Year:

1989

Language:

english

File:

PDF, 543 KB

english, 1989

49

Book reviews

Mealor, D., Richards, C. P., Young, Roger, Aherne, G. Wynne, Evans, M. B., Burgess, C.

Journal:

The Analyst (Royal Society of Chemistry)

Year:

1991

Language:

english

File:

PDF, 488 KB

english, 1991

50

Vinblastine Pharmacokinetics in Patients with Non-Small Cell Lung Cancer Given Cisplatin

Links, Matthew, Watson, Shaun, Lethlean, Keith, Aherne, Wynne, Kirsten, Fred, Clarke, Stephen, Law, Matthew, Friedlander, Michael, Galettis, Peter, McKeage, Mark J.

Journal:

Cancer Investigation

Year:

1999

Language:

english

File:

PDF, 549 KB

english, 1999